Niclosamide Formulations and Methods of Use

Niclosamide is widely used as an oral medication for various tapeworm infections and has also been shown to be effective inhibitor of viral replication and infection.  The invention involves a  Niclosamide formulation utilizing permeability enhancers used to increase the amount of Niclosamide capable of being taken up by cells. The Niclosamide formulation has been shown to increase cellular uptake by as much as 150%. This Niclosamide formulation may be used to enhance delivery of Niclosamide in the treatment of human coronavirus or flavivirus infections.